2-Fluoromethamphetamine (2-FMA) is a phenethylamine and amphetamine that’s been used since around 2012. It’s a research chemical and little formal knowledge about the substance is available.
It’s been described as an alternative to amphetamine and lisdexamfetamine, albeit with a lower recreational potential. 2-FMA primarily offers productive rather than recreational effects. Most users describe it as less inherently recreational than amphetamine.
Increased heart rate
Increased blood pressure
It’s largely a functional/productive stimulant rather than a euphoric and inherently recreational substance. Many users describe it as “clean,” with it being good for productivity and relatively free from negative physical effects. It’s not very “pushy.”
The effects have been described as “calm.” A lot of users find they can get the stimulation they’re looking for without feeling like they’re on a strong stimulant. Usually people don’t end up overflowing with energy to the point that sitting down and working is difficult, something that can occur with certain stimulants.
While you may be happier while on the drug, it’s not very euphoric. And even though it can offer an increase in motivation, becoming incredibly happy regardless of what you’re working on isn’t as common.
Some people have compared it to lisdexamfetamine. Both are fairly long-lasting and good for productivity at common doses. However, 2-FMA tends to have a lower recreational potential than lisdexamfetamine or amphetamine.
There haven been cases of people using it daily or near daily, occasionally as an alternative for prescription amphetamines. Since less is known about 2-FMA, this isn’t recommended.
The drug is typically more enjoyable and noticeable than modafinil, but they’re both more productive than recreational.
As long as you take a common dose, it’s usually free of most negative effects. This means little to no jitteriness, noticeable cardiovascular effects, sweating, or anxiety.
With higher doses (e.g. over 50 mg), jitteriness, sweating, jaw tightness, muscle tension, and possibly heart palpitations can develop.
Comedown & after effects
Most users find 2-FMA leads to effectively no comedown or after effects when taken at common doses.
Strong+ doses can lead to some negative after effects, including transient low mood, low motivation, a flat affect, and even moderate depression into the following day.
A combination known as the “Borax Combo” has gained some attention online. It can include various substances with the goal of offering an MDMA-like effect.
One of the combinations is 2-FMA, 5-MAPB, and 4-HO-MET. 2-FMA is largely just offering stimulation in that combo.
We don’t know how safe combining those drugs is, but if taken like MDMA (e.g. every few months) it’s probably not too concerning for healthy people.
Chemistry & Pharmacology
Chemistry 2-FMA is a substituted amphetamine. It’s a member of a group of fluorinated amphetamine derivatives, which also features substances like 2-FA and 4-FA.
We don’t know its mechanism due to a lack of research. An educated guess is that it’s functioning as a reuptake inhibitor and releasing agent, particularly for dopamine and norepinephrine.
There could potentially be other actions, such as at VMAT2 and TAAR1.